Great question. I'm the founder of several recruiting services including a recent startup focused in delivering video resumes so I hope my answer comes with value!

Hiring managers are busy, and for the most part find it tedious to review resumes and cover letters. Is a fact that your resume shouldn't be more than 2 pages and that they only get 6sec average scan. Those seconds are spent quickly to catch your name, most relevant experience, most bottom experience overview and education...
When employers ask "tell me about yourself" they are not (for the most part- generally speaking) asking about your hobbies (that might come later). You need to assume that the manager wants high turnover time in those interviews so that question should lead to you summarizing your career for them...
You starter working at age:
First job was__ & learned ___.
Other experiences related to the position were acquired doing:____ and have a degree or years experience of ______. And now looking to further expand your career and put into practice all that you have learned to date.

A company that values their culture will most likely have cultural related questions.. There feel free to express your hobbies but only as their relevance to the job allows.
If you get a second interview with possible coworkers that means culture is huge.. So embrace and imitate their style and make friends not professional intro at that point except for when they ask job related questions.

Hope it helps & best of luck!! That the fact that you ask makes you probably a great candidate already!