Founder of two successful companies. Experienced in growing and managing teams. Tactical skills in raising capital, product development, enterprise sales, predictable sales process, and operational process. Mentor at Nashville Entrepreneur Center. Mentor at Jumpstart Foundry. Entrepreneur. Enterprise healthcare sales. Advisor at Imogene + Willie. Advisor at Sevier Skirts.
This decision depends primarily on your market and the specific needs.
Outside of knowing this key element, my initial reaction is that building a web application that is mobile friendly is a great option to start. If native apps (for various platforms) are desired to continue building your client base, then you can come in well informed from your base web application.