In a startup with a globally-spread remote team, does it still make sense to incorporate in U.S./Delaware vs. somewhere overseas?

I'm a Canadian citizen/resident and startup founder, my co-founder is an American citizen/resident living in San Francisco, we've got one employee who's also American living in Colorado. We expect a handful of American employees and handful of globally dispersed employees from outside the U.S. Does it make sense to incorporate in Delaware? Some possible advantages that are on our mind to not incorporating in Delaware: - As a Canadian, I can't visit the states while working for our company if it's a U.S. incorporated company - but I can visit up to 6 months if it's a non-U.S. company. - Lower Taxes - Simpler law / less bureaucracy Some possible disadvantages: - Harder to raise money - Harder to IPO - Harder to get an acquisition - Negative tax implications we're not aware of When you've got a physical office the "where to incorporate" question is straightforward, but when you've got a remote team of multiple nationalities it gets complicated and we're unsure how to weight these options. Does it make sense for a globally dispersed team to incorporate in Delaware?