As a lifelong student, i've come to understand what sitting does to the human body. Generally-speaking, people who sit in (and thus outsource their skeletomusculature system to) chairs for extended periods of time will develop very predictable mobility issues, which leads towards a loss of physical function. This has many implications.
Then you must consider myriad of other factors... Sitting (especially in the same environment) causes brain atrophy, and negatively impacts our glymphatic system, metabolism, and ability to control blood sugar.
Bottom line: Humans aren't meant to be sedentary. Sitting in excess creates many problems. Move or die.